Elevated levels of amyloid-β peptide (Aβ) in the human brain are linked to the pathogenesis
of Alzheimer disease. Recent in vitro studies have demonstrated that extracellular Aβ can
bind to exosomes, which are cell-secreted nanovesicles with lipid membranes that are
known to transport their cargos intercellularly. Such findings suggest that the exosomes are
involved in Aβ metabolism in brain. Here, we found that neuroblastoma-derived exosomes
exogenously injected into mouse brains trapped Aβ and with the associated Aβ were …