[HTML][HTML] Mechanism of evenness interrupted (Evi)-exosome release at synaptic boutons

K Koles, J Nunnari, C Korkut, R Barria, C Brewer… - Journal of Biological …, 2012 - ASBMB
Wnt signaling plays critical roles during synaptic development and plasticity. However, the
mechanisms by which Wnts are released and travel to target cells are unresolved. During
synaptic development, the secretion of Drosophila Wnt1, Wingless, requires the function of
Evenness Interrupted (Evi)/Wls, a Wingless-binding protein that is secreted along with
Wingless at the neuromuscular junction. Given that Evi is a transmembrane protein, these
studies suggested the presence of a novel vesicular mechanism of trans-synaptic …