IFNγ-stimulated dendritic cell exosomes as a potential therapeutic for remyelination
AD Pusic, KM Pusic, BLL Clayton, RP Kraig - Journal of neuroimmunology, 2014 - Elsevier
Dendritic cells (DCs) release exosomes with different characteristics based on stimulus.
Here, we showed that DC cultures stimulated with low-level IFNγ released exosomes (IFNγ-
DC-Exos) that contained microRNA species that can increase baseline myelination, reduce
oxidative stress, and improve remyelination following acute lysolecithin-induced
demyelination. Furthermore, nasally administered IFNγ-DC-Exos increased CNS
myelination in vivo. IFNγ-DC-Exos were preferentially taken up by oligodendrocytes …
Here, we showed that DC cultures stimulated with low-level IFNγ released exosomes (IFNγ-
DC-Exos) that contained microRNA species that can increase baseline myelination, reduce
oxidative stress, and improve remyelination following acute lysolecithin-induced
demyelination. Furthermore, nasally administered IFNγ-DC-Exos increased CNS
myelination in vivo. IFNγ-DC-Exos were preferentially taken up by oligodendrocytes …