Subretinal transplantation of bone marrow mesenchymal stem cells delays retinal degeneration in the RCS rat model of retinal degeneration

Y Inoue, A Iriyama, S Ueno, H Takahashi… - Experimental eye …, 2007 - Elsevier
Because there is no effective treatment for this retinal degeneration, potential application of
cell-based therapy has attracted considerable attention. Several investigations support that
bone marrow mesenchymal stem cells (MSCs) can be used for a broad spectrum of
indications. Bone marrow MSCs exert their therapeutic effect in part by secreting trophic
factors to promote cell survival. The current study investigates whether bone marrow MSCs
secrete factor (s) to promote photoreceptor cell survival and whether subretinal …