The neuroprotective effects of z-DEVD. fmk, a caspase-3 inhibitor, on traumatic spinal cord injury in rats
Ş Barut, YA Ünlü, A Karaoğlan, M Tunçdemir… - Surgical neurology, 2005 - Elsevier
BACKGROUND: Apoptosis is one of the most important forms of cell death seen in a variety
of physiological and pathological conditions, including traumatic injuries. This type of cell
death occurs via mediators known as caspases. Previous studies have investigated the
roles that apoptosis and different caspases play in the pathogenesis of secondary damage
after spinal cord injury (SCI). The aim of this research was to assess the neuroprotective
effect of z-DEVD. fmk, a caspase-3 inhibitor, in a rat model of SCI. METHODS: Forty-five …
of physiological and pathological conditions, including traumatic injuries. This type of cell
death occurs via mediators known as caspases. Previous studies have investigated the
roles that apoptosis and different caspases play in the pathogenesis of secondary damage
after spinal cord injury (SCI). The aim of this research was to assess the neuroprotective
effect of z-DEVD. fmk, a caspase-3 inhibitor, in a rat model of SCI. METHODS: Forty-five …