[HTML][HTML] Discarded human thymus is a novel source of stable and long-lived therapeutic regulatory T cells
IE Dijke, RE Hoeppli, T Ellis, J Pearcey… - American Journal of …, 2016 - Elsevier
Regulatory T cell (Treg)–based therapy is a promising approach to treat many immune-
mediated disorders such as autoimmune diseases, organ transplant rejection, and graft-
versus-host disease (GVHD). Challenges to successful clinical implementation of adoptive
Treg therapy include difficulties isolating homogeneous cell populations and developing
expansion protocols that result in adequate numbers of cells that remain stable, even under
inflammatory conditions. We investigated the potential of discarded human thymuses …
mediated disorders such as autoimmune diseases, organ transplant rejection, and graft-
versus-host disease (GVHD). Challenges to successful clinical implementation of adoptive
Treg therapy include difficulties isolating homogeneous cell populations and developing
expansion protocols that result in adequate numbers of cells that remain stable, even under
inflammatory conditions. We investigated the potential of discarded human thymuses …