Decreased binding of insulin to its receptors in rats with hormone induced insulin resistance
ID Goldfine, CR Kahn, DM Neville Jr, J Roth… - Biochemical and …, 1973 - Elsevier
ID Goldfine, CR Kahn, DM Neville Jr, J Roth, MM Garrison, RW Bates
Biochemical and Biophysical Research Communications, 1973•ElsevierInsulin and glucagon receptor binding was studied in purified liver membranes from rats
made insulin resistant by implantation of an MtT pituitary tumor which secretes growth
hormone, prolactin, and ACTH. Insulin binding to its receptors was decreased and
correlated with the degree of insulin resistance. In contrast, binding of glucagon to its
receptors was unchanged.
made insulin resistant by implantation of an MtT pituitary tumor which secretes growth
hormone, prolactin, and ACTH. Insulin binding to its receptors was decreased and
correlated with the degree of insulin resistance. In contrast, binding of glucagon to its
receptors was unchanged.
Abstract
Insulin and glucagon receptor binding was studied in purified liver membranes from rats made insulin resistant by implantation of an MtT pituitary tumor which secretes growth hormone, prolactin, and ACTH. Insulin binding to its receptors was decreased and correlated with the degree of insulin resistance. In contrast, binding of glucagon to its receptors was unchanged.
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