[HTML][HTML] Increased P85α is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone …

LA Barbour, SM Rahman, I Gurevich, JW Leitner… - Journal of Biological …, 2005 - ASBMB
Insulin resistance is a cardinal feature of normal pregnancy and excess growth hormone
(GH) states, but its underlying mechanism remains enigmatic. We previously found a
significant increase in the p85 regulatory subunit of phosphatidylinositol kinase (PI 3-kinase)
and striking decrease in IRS-1-associated PI 3-kinase activity in the skeletal muscle of
transgenic animals overexpressing human placental growth hormone. Herein, using
transgenic mice bearing deletions in p85α, p85β, or insulin-like growth factor-1, we provide …