IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancer
D Lu, X Yang, NY Jiang, BA Woda, Q Liu… - The American journal …, 2011 - journals.lww.com
The expression of IMP3, an oncofetal protein, has been strongly associated with aggressive
cancers. In this study, we investigated whether IMP3 can serve as a biomarker to predict
invasive squamous cell carcinoma (SCC) in patients with cervical intraepithelial neoplasia
(CIN) II and III. A total of 1249 patients with no dysplasia, CINs, or invasive SCC were
studied for IMP3 expression. The 710 patients with CIN II and III in their cervical biopsies
were further evaluated for invasive cancer-free survival analysis. The role of IMP3 in the …
cancers. In this study, we investigated whether IMP3 can serve as a biomarker to predict
invasive squamous cell carcinoma (SCC) in patients with cervical intraepithelial neoplasia
(CIN) II and III. A total of 1249 patients with no dysplasia, CINs, or invasive SCC were
studied for IMP3 expression. The 710 patients with CIN II and III in their cervical biopsies
were further evaluated for invasive cancer-free survival analysis. The role of IMP3 in the …