IMP3 as a supplemental diagnostic marker for Hodgkin lymphoma
H Tang, Q Wei, J Ge, W Jian, J Liu, L Zhong, B Fu… - Human pathology, 2013 - Elsevier
Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is ubiquitously expressed in
embryos, mediating organogenesis, RNA trafficking, and cell growth, and is generally down-
regulated in adult tissue. However, IMP3 has recently been shown to be overexpressed in
some malignant epithelial neoplasms and to be a useful diagnostic and/or prognostic
biomarker for several carcinomas. To determine whether IMP3 might also be an accurate
biomarker of Hodgkin lymphoma, we examined 81 Hodgkin lymphomas for immunoreactivity …
embryos, mediating organogenesis, RNA trafficking, and cell growth, and is generally down-
regulated in adult tissue. However, IMP3 has recently been shown to be overexpressed in
some malignant epithelial neoplasms and to be a useful diagnostic and/or prognostic
biomarker for several carcinomas. To determine whether IMP3 might also be an accurate
biomarker of Hodgkin lymphoma, we examined 81 Hodgkin lymphomas for immunoreactivity …