Octanoic acid in alcohol-responsive essential tremor: a randomized controlled study

D Haubenberger, G McCrossin, C Lungu, E Considine… - Neurology, 2013 - AAN Enterprises
D Haubenberger, G McCrossin, C Lungu, E Considine, C Toro, FB Nahab, S Auh…
Neurology, 2013AAN Enterprises
Objective: To assess safety and efficacy of an oral, single, low dose of octanoic acid (OA) in
subjects with alcohol-responsive essential tremor (ET). Methods: We conducted a double-
blind, placebo-controlled, crossover, phase I/II clinical trial evaluating the effect of 4 mg/kg
OA in 19 subjects with ET. The primary outcome was accelerometric postural tremor power
of the dominant hand 80 minutes after administration. Secondary outcomes included digital
spiral analysis, pharmacokinetic sampling, as well as safety measures. Results: OA was safe …
Objective
To assess safety and efficacy of an oral, single, low dose of octanoic acid (OA) in subjects with alcohol-responsive essential tremor (ET).
Methods
We conducted a double-blind, placebo-controlled, crossover, phase I/II clinical trial evaluating the effect of 4 mg/kg OA in 19 subjects with ET. The primary outcome was accelerometric postural tremor power of the dominant hand 80 minutes after administration. Secondary outcomes included digital spiral analysis, pharmacokinetic sampling, as well as safety measures.
Results
OA was safe and well tolerated. Nonserious adverse events were mild (Common Terminology Criteria for Adverse Events grade 1) and equally present after OA and placebo. At the primary outcome, OA effects were not different from placebo. Secondary outcome analyses of digital spiral analysis, comparison across the entire time course in weighted and nonweighted accelerometry, as well as nondominant hand tremor power did not show a benefit of OA over placebo. The analysis of individual time points showed that OA improved tremor at 300 minutes (dominant hand, F1,16 = 5.49, p = 0.032 vs placebo), with a maximum benefit at 180 minutes after OA (both hands, F1,16 = 6.1, p = 0.025).
Conclusions
Although the effects of OA and placebo at the primary outcome were not different, secondary outcome measures suggest superiority of OA in reducing tremor at later time points, warranting further trials at higher dose levels.
Classification of evidence
This study provides Class I evidence that a single 4-mg/kg dose of OA is not effective in reducing postural tremor in patients with ET at a primary outcome of 80 minutes, but is effective for a secondary outcome after 180 minutes.
American Academy of Neurology