[HTML][HTML] Crystal structures of the Dab homology domains of mouse disabled 1 and 2
M Yun, L Keshvara, CG Park, JB Dickerson… - Journal of Biological …, 2003 - ASBMB
Disabled (Dab) 1 and 2 are mammalian homologues of Drosophila DAB. Dab1 is a key
cytoplasmic mediator in Reelin signaling that controls cell positioning in the developing
central nervous system, whereas Dab2 is an adapter protein that plays a role in endocytosis.
DAB family proteins possess an amino-terminal DAB homology (DH) domain that is similar
to the phosphotyrosine binding/phosphotyrosine interaction (PTB/PI) domain. We have
solved the structures of the DH domains of Dab2 (Dab2-DH) and Dab1 (Dab1-DH) in three …
cytoplasmic mediator in Reelin signaling that controls cell positioning in the developing
central nervous system, whereas Dab2 is an adapter protein that plays a role in endocytosis.
DAB family proteins possess an amino-terminal DAB homology (DH) domain that is similar
to the phosphotyrosine binding/phosphotyrosine interaction (PTB/PI) domain. We have
solved the structures of the DH domains of Dab2 (Dab2-DH) and Dab1 (Dab1-DH) in three …