Exosomal communication goes viral

DG Meckes Jr - Journal of virology, 2015 - Am Soc Microbiol
Journal of virology, 2015Am Soc Microbiol
Exosomes are small vesicles secreted from cells that participate in intercellular
communication events. Accumulating evidence demonstrates that host exosome pathways
are hijacked by viruses and that virally modified exosomes contribute to virus spread and
immune evasion. In the case of tumor viruses, recent findings suggest that alterations in
normal exosome biology may promote the development and progression of cancer. These
studies will be discussed in the context of our current knowledge of Epstein-Barr virus (EBV) …
Abstract
Exosomes are small vesicles secreted from cells that participate in intercellular communication events. Accumulating evidence demonstrates that host exosome pathways are hijacked by viruses and that virally modified exosomes contribute to virus spread and immune evasion. In the case of tumor viruses, recent findings suggest that alterations in normal exosome biology may promote the development and progression of cancer. These studies will be discussed in the context of our current knowledge of Epstein-Barr virus (EBV)-modified exosomes.
American Society for Microbiology