[HTML][HTML] Exosome uptake depends on ERK1/2-heat shock protein 27 signaling and lipid Raft-mediated endocytosis negatively regulated by caveolin-1
KJ Svensson, HC Christianson, A Wittrup… - Journal of Biological …, 2013 - ASBMB
The role of exosomes in cancer can be inferred from the observation that they transfer tumor
cell derived genetic material and signaling proteins, resulting in eg increased tumor
angiogenesis and metastasis. However, the membrane transport mechanisms and the
signaling events involved in the uptake of these virus-like particles remain ill-defined. We
now report that internalization of exosomes derived from glioblastoma (GBM) cells involves
nonclassical, lipid raft-dependent endocytosis. Importantly, we show that the lipid raft …
cell derived genetic material and signaling proteins, resulting in eg increased tumor
angiogenesis and metastasis. However, the membrane transport mechanisms and the
signaling events involved in the uptake of these virus-like particles remain ill-defined. We
now report that internalization of exosomes derived from glioblastoma (GBM) cells involves
nonclassical, lipid raft-dependent endocytosis. Importantly, we show that the lipid raft …