[HTML][HTML] Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps
N Maugeri, L Campana, M Gavina, C Covino… - Journal of Thrombosis …, 2014 - Elsevier
Background Increasing evidence implicates both platelets and neutrophils in the formation,
stabilization, and growth of peripheral and coronary thrombi. Neutrophil extracellular traps
(NETs) play a key role. The early events in the deregulated cross‐talk between platelets and
neutrophils are poorly characterized. Objectives To identify at the molecular level the
mechanism through which platelets induce the generation of NETs in sterile conditions.
Patients/Methods The presence of NETs was determined in 26 thrombi from patients with …
stabilization, and growth of peripheral and coronary thrombi. Neutrophil extracellular traps
(NETs) play a key role. The early events in the deregulated cross‐talk between platelets and
neutrophils are poorly characterized. Objectives To identify at the molecular level the
mechanism through which platelets induce the generation of NETs in sterile conditions.
Patients/Methods The presence of NETs was determined in 26 thrombi from patients with …