Lung function and airway hyperresponsiveness in adult patients with sickle cell disease

EC Vendramini, EO Vianna, IDL Šngulo… - The American journal of …, 2006 - Elsevier
Background Lung disease is a major cause of morbidity and death in sickle cell disease.
Although airway hyperresponsiveness has been noted in children, there are no studies in
adult sickle cell patients. The aim of this study was to investigate the prevalence of airway
hyperresponsiveness in adult sickle cell patients. Methods Twenty-six patients with sickle
cell disease (10 HbSC, 9 HbSS, and 7 HbSβ) were compared with 28 normal control
subjects. Pulmonary function tests, including spirometry, measurements of single-breath …