Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production
Background Cysteinyl leukotrienes (CysLTs) contribute to asthma pathogenesis, in part
through cysteinyl leukotriene receptor 1 (CysLT1R). Recently discovered lineage-negative
type 2 innate lymphoid cells (ILC2s) potently produce IL-5 and IL-13. Objectives We
hypothesized that lung ILC2s might be activated by leukotrienes through CysLT1R. Methods
ILC2s (Thy1. 2+ lineage-negative lymphocytes) and CysLT1R were detected in the lungs of
wild-type, signal transducer and activator of transcription 6–deficient (STAT6−/−), and …
through cysteinyl leukotriene receptor 1 (CysLT1R). Recently discovered lineage-negative
type 2 innate lymphoid cells (ILC2s) potently produce IL-5 and IL-13. Objectives We
hypothesized that lung ILC2s might be activated by leukotrienes through CysLT1R. Methods
ILC2s (Thy1. 2+ lineage-negative lymphocytes) and CysLT1R were detected in the lungs of
wild-type, signal transducer and activator of transcription 6–deficient (STAT6−/−), and …