[HTML][HTML] Body fluid exosomes promote secretion of inflammatory cytokines in monocytic cells via Toll-like receptor signaling
NP Bretz, J Ridinger, AK Rupp, K Rimbach… - Journal of Biological …, 2013 - ASBMB
Tumor-derived exosomes have been shown to induce various immunomodulatory effects.
However, the underlying signaling pathways are poorly understood. Here, we analyzed the
effects of ex vivo-derived exosomes on monocytic cell differentiation/activation using THP-1
cells as model. We isolated exosomes from various body fluids such as amniotic fluid, liver
cirrhosis ascites, and malignant ascites of ovarian cancer patients. We observed that
exosomes were internalized by THP-1 cells and induced the production of IL-1β, TNF-α, and …
However, the underlying signaling pathways are poorly understood. Here, we analyzed the
effects of ex vivo-derived exosomes on monocytic cell differentiation/activation using THP-1
cells as model. We isolated exosomes from various body fluids such as amniotic fluid, liver
cirrhosis ascites, and malignant ascites of ovarian cancer patients. We observed that
exosomes were internalized by THP-1 cells and induced the production of IL-1β, TNF-α, and …