MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis

JB Kopp, MW Smith, GW Nelson, RC Johnson… - Nature …, 2008 - nature.com
JB Kopp, MW Smith, GW Nelson, RC Johnson, BI Freedman, DW Bowden, T Oleksyk
Nature genetics, 2008nature.com
The increased burden of chronic kidney and end-stage kidney diseases (ESKD) in
populations of African ancestry has been largely unexplained. To identify genetic variants
predisposing to idiopathic and HIV-1–associated focal segmental glomerulosclerosis
(FSGS), we carried out an admixture-mapping linkage-disequilibrium genome scan on 190
African American individuals with FSGS and 222 controls. We identified a chromosome 22
region with a genome-wide logarithm of the odds (lod) score of 9.2 and a peak lod of 12.4 …
Abstract
The increased burden of chronic kidney and end-stage kidney diseases (ESKD) in populations of African ancestry has been largely unexplained. To identify genetic variants predisposing to idiopathic and HIV-1–associated focal segmental glomerulosclerosis (FSGS), we carried out an admixture-mapping linkage-disequilibrium genome scan on 190 African American individuals with FSGS and 222 controls. We identified a chromosome 22 region with a genome-wide logarithm of the odds (lod) score of 9.2 and a peak lod of 12.4 centered on MYH9, a functional candidate gene expressed in kidney podocytes. Multiple MYH9 SNPs and haplotypes were recessively associated with FSGS, most strongly a haplotype spanning exons 14 through 23 (OR = 5.0, 95% CI = 3.5–7.1; P = 4 × 10−23, n = 852). This association extended to hypertensive ESKD (OR = 2.2, 95% CI = 1.5–3.4; n = 433), but not type 2 diabetic ESKD (n = 476). Genetic variation at the MYH9 locus substantially explains the increased burden of FSGS and hypertensive ESKD among African Americans.
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