In vivo time-lapse imaging of mitochondria in healthy and diseased peripheral myelin sheath

S Gonzalez, R Fernando, J Berthelot, C Perrin-Tricaud… - Mitochondrion, 2015 - Elsevier
The myelin sheath that covers a large amount of neurons is critical for their homeostasis,
and myelinating glia mitochondria have recently been shown to be essential for neuron
survival. However morphological and physiological properties of these organelles remain
elusive. Here we report a method to analyze mitochondrial dynamics and morphology in
myelinating Schwann cells of living mice using viral transduction and time-lapse multiphoton
microscopy. We describe the distribution, shape, size and dynamics of mitochondria in live …