[HTML][HTML] Mast cells produce novel shorter forms of perlecan that contain functional endorepellin: a role in angiogenesis and wound healing
Mast cells are derived from hematopoietic progenitors that are known to migrate to and
reside within connective and mucosal tissues, where they differentiate and respond to
various stimuli by releasing pro-inflammatory mediators, including histamine, growth factors,
and proteases. This study demonstrated that primary human mast cells as well as the rat and
human mast cell lines, RBL-2H3 and HMC-1, produce the heparan sulfate proteoglycan,
perlecan, with a molecular mass of 640 kDa as well as smaller molecular mass species of …
reside within connective and mucosal tissues, where they differentiate and respond to
various stimuli by releasing pro-inflammatory mediators, including histamine, growth factors,
and proteases. This study demonstrated that primary human mast cells as well as the rat and
human mast cell lines, RBL-2H3 and HMC-1, produce the heparan sulfate proteoglycan,
perlecan, with a molecular mass of 640 kDa as well as smaller molecular mass species of …