Arthrogryposis multiplex congenita: etiology, genetics, classification, diagnostic approach, and general aspects

JG Hall - Journal of Pediatric Orthopaedics B, 1997 - journals.lww.com
Arthrogryposis is a sign associated with many specific conditions and syndromes. It is a term
used to describe the presence of multiple joint contractures that are present at birth. It can be
seen in isolation or in association with other congenital abnormalities as part of a syndrome
with or without central nervous system involvement. The exact pathogenesis of
arthrogryposis is unknown, but all involve fetal akinesia (decreased fetal movement) with
subsequent joint contractures. In this article I describe the causes, genetic aspects …