[HTML][HTML] The restriction factors of human immunodeficiency virus
RS Harris, JF Hultquist, DT Evans - Journal of Biological Chemistry, 2012 - ASBMB
Cellular proteins called" restriction factors" can serve as powerful blockades to HIV
replication, but the virus possesses elaborate strategies to circumvent these barriers. First,
we discuss general hallmarks of a restriction factor. Second, we review how the viral Vif
protein protects the viral genome from lethal levels of cDNA deamination by promoting
APOBEC3 protein degradation; how the viral Vpu, Env, and Nef proteins facilitate
internalization and degradation of the virus-tethering protein BST-2/tetherin; and how the …
replication, but the virus possesses elaborate strategies to circumvent these barriers. First,
we discuss general hallmarks of a restriction factor. Second, we review how the viral Vif
protein protects the viral genome from lethal levels of cDNA deamination by promoting
APOBEC3 protein degradation; how the viral Vpu, Env, and Nef proteins facilitate
internalization and degradation of the virus-tethering protein BST-2/tetherin; and how the …