Tetraspanins in the immune response against cancer

S Veenbergen, AB van Spriel - Immunology Letters, 2011 - Elsevier
The role of the immune system in the defense against cancer, a process termed tumor
immunosurveillance, has been extensively studied. Evidence is accumulating that the
molecular organization of proteins and lipids in the plasma membrane of immune cells is of
critical importance. Tetraspanin proteins are expressed in the plasma membrane of all
mammalian cells and play an important role in the spatial organization of partner molecules
into tetraspanin-enriched microdomains. It is now well established that tetraspanins interact …