Coinhibitory receptors and CD8 T cell exhaustion in chronic infections
VK Kuchroo, AC Anderson… - Current Opinion in HIV …, 2014 - journals.lww.com
Current Opinion in HIV and AIDS, 2014•journals.lww.com
Revealing the molecular basis of virus-specific CD8 T cell exhaustion in chronic infections is
critical for the understanding of the disease pathogenesis and the designing of novel
vaccines aiming to enhance the cytolytic arm of the immune system. This is of particular
interest for the development of immunotherapies in the context of a functional cure for HIV.
critical for the understanding of the disease pathogenesis and the designing of novel
vaccines aiming to enhance the cytolytic arm of the immune system. This is of particular
interest for the development of immunotherapies in the context of a functional cure for HIV.
Summary
Revealing the molecular basis of virus-specific CD8 T cell exhaustion in chronic infections is critical for the understanding of the disease pathogenesis and the designing of novel vaccines aiming to enhance the cytolytic arm of the immune system. This is of particular interest for the development of immunotherapies in the context of a functional cure for HIV.
Lippincott Williams & Wilkins