[HTML][HTML] Negative elongation factor NELF represses human immunodeficiency virus transcription by pausing the RNA polymerase II complex
Z Zhang, A Klatt, DS Gilmour, AJ Henderson - Journal of Biological …, 2007 - ASBMB
Human immunodeficiency virus (HIV) transcription requires virally encoded Tat and the P-
TEFb protein complex, which together associate with the Tat-activating region, a structured
region in the nascent transcript. P-TEFb phosphorylates Proteins in the transcription
elongation complex, including RNA polymerase II (pol II), to stimulate elongation and to
overcome premature termination. However, the status of the elongation complex on the HIV
long terminal repeat (LTR) in a repressed state is not known. Chromatin …
TEFb protein complex, which together associate with the Tat-activating region, a structured
region in the nascent transcript. P-TEFb phosphorylates Proteins in the transcription
elongation complex, including RNA polymerase II (pol II), to stimulate elongation and to
overcome premature termination. However, the status of the elongation complex on the HIV
long terminal repeat (LTR) in a repressed state is not known. Chromatin …