[HTML][HTML] Transcription factors ER71/ETV2 and SOX9 participate in a positive feedback loop in fetal and adult mouse testis
ER71, also known as ETV2, is an ETS transcription factor that is expressed during
embryogenesis and in adult testes. We show that Er71 transcription can be up-regulated by
SRY, the key determinant of male differentiation. Accordingly, SRY bound to and activated
the Er71 promoter, and mutation of a putative SRY binding site abolished this promoter
activation. In turn, ER71 was able to bind to the promoter of Sox9, the primary target of SRY
and a critical transcription factor for maintenance of the Sertoli cell phenotype. Mutation of …
embryogenesis and in adult testes. We show that Er71 transcription can be up-regulated by
SRY, the key determinant of male differentiation. Accordingly, SRY bound to and activated
the Er71 promoter, and mutation of a putative SRY binding site abolished this promoter
activation. In turn, ER71 was able to bind to the promoter of Sox9, the primary target of SRY
and a critical transcription factor for maintenance of the Sertoli cell phenotype. Mutation of …