Evidence for a genomic mechanism of action for progesterone receptor membrane component-1
JJ Peluso, J DeCerbo, V Lodde - Steroids, 2012 - Elsevier
Progesterone receptor membrane component 1 (PGRMC1) is highly expressed in the
granulosa and luteal cells of rodent and primate ovaries. Interestingly, its molecular weight
as assessed by Western blot is dependent on its cellular localization with a≈ 27kDa form
being detected in the cytoplasm and higher molecular weight forms being detected in the
nucleus. The higher molecular weight forms of PGRMC1 are sumoylated suggesting that
they are involved in regulating gene transcription, since sumoylation of nuclear proteins …
granulosa and luteal cells of rodent and primate ovaries. Interestingly, its molecular weight
as assessed by Western blot is dependent on its cellular localization with a≈ 27kDa form
being detected in the cytoplasm and higher molecular weight forms being detected in the
nucleus. The higher molecular weight forms of PGRMC1 are sumoylated suggesting that
they are involved in regulating gene transcription, since sumoylation of nuclear proteins …