[HTML][HTML] Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter
O Korchynskyi, P Ten Dijke - Journal of Biological Chemistry, 2002 - ASBMB
Transforming growth factor-β (TGF-β) family members, which include bone morphogenetic
proteins (BMPs) and TGF-βs, elicit their cellular effects by activating specific Smad proteins,
which control the transcription of target genes. BMPs and TGF-βs have overlapping as well
as specific effects on mesenchymal cell differentiation for which the mechanisms are
incompletely understood. Here we report that Id1, a dominant negative inhibitor of basic
helix-loop-helix proteins, is a direct target gene for BMP. BMP, but not TGF-β, strongly …
proteins (BMPs) and TGF-βs, elicit their cellular effects by activating specific Smad proteins,
which control the transcription of target genes. BMPs and TGF-βs have overlapping as well
as specific effects on mesenchymal cell differentiation for which the mechanisms are
incompletely understood. Here we report that Id1, a dominant negative inhibitor of basic
helix-loop-helix proteins, is a direct target gene for BMP. BMP, but not TGF-β, strongly …