[HTML][HTML] Proteomic analysis of altered extracellular matrix turnover in bleomycin-induced pulmonary fibrosis
ML Decaris, M Gatmaitan, S FlorCruz, F Luo… - Molecular & Cellular …, 2014 - ASBMB
Fibrotic disease is characterized by the pathological accumulation of extracellular matrix
(ECM) proteins. Surprisingly, very little is known about the synthesis and degradation rates
of the many proteins and proteoglycans that constitute healthy or pathological extracellular
matrix. A comprehensive understanding of altered ECM protein synthesis and degradation
during the onset and progression of fibrotic disease would be immensely valuable. We have
developed a dynamic proteomics platform that quantifies the fractional synthesis rates of …
(ECM) proteins. Surprisingly, very little is known about the synthesis and degradation rates
of the many proteins and proteoglycans that constitute healthy or pathological extracellular
matrix. A comprehensive understanding of altered ECM protein synthesis and degradation
during the onset and progression of fibrotic disease would be immensely valuable. We have
developed a dynamic proteomics platform that quantifies the fractional synthesis rates of …