[HTML][HTML] Mass spectrometric identification of increased C16 ceramide levels during apoptosis

RL Thomas, CM Matsko, MT Lotze… - Journal of Biological …, 1999 - ASBMB
A variety of molecular changes occur during the process of apoptosis. Much of the recent
work has focused on changes in critical cellular proteins, proteins necessary for the initiation
and continuation of the apoptotic process. Given the fact that numerous membrane changes
occur throughout the apoptotic process, we initiated an investigation aimed at determining
the major lipid changes that occurred during programmed cell death. When ionizing
radiation was used to initiate the apoptotic process in Jurkat cells, one of the major changes …