Popeye domain-containing proteins and stress-mediated modulation of cardiac pacemaking

S Simrick, RF Schindler, KL Poon, T Brand - Trends in cardiovascular …, 2013 - Elsevier
An intricate network of ion channels and pumps are involved in generating a diastolic
pacemaker potential, which is transmitted to the working myocardium with the help of the
cardiac conduction system. The principles of cardiac pacemaking are reasonably well
understood, however, the mechanism by which the heart increases its beating frequency in
response to adrenergic stimulation has not been fully worked out. The Popeye domain-
containing (Popdc) genes encode plasma membrane-localized proteins that are able to bind …