Discoidin domain receptor functions in physiological and pathological conditions
B Leitinger - International review of cell and molecular biology, 2014 - Elsevier
The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors that
are members of the receptor tyrosine kinase family. Both DDRs bind a number of different
collagen types and play important roles in embryo development. Dysregulated DDR function
is associated with progression of various human diseases, including fibrosis, arthritis, and
cancer. By interacting with key components of the extracellular matrix and displaying distinct
activation kinetics, the DDRs form a unique subfamily of receptor tyrosine kinases. DDR …
are members of the receptor tyrosine kinase family. Both DDRs bind a number of different
collagen types and play important roles in embryo development. Dysregulated DDR function
is associated with progression of various human diseases, including fibrosis, arthritis, and
cancer. By interacting with key components of the extracellular matrix and displaying distinct
activation kinetics, the DDRs form a unique subfamily of receptor tyrosine kinases. DDR …