The type III inositol 1, 4, 5-trisphosphate receptor is associated with aggressiveness of colorectal carcinoma
K Shibao, MJ Fiedler, J Nagata, N Minagawa, K Hirata… - Cell calcium, 2010 - Elsevier
The inositol 1, 4, 5-trisphosphate receptor (InsP3R) mediates Ca2+ signaling in epithelia
and regulates cellular functions such as secretion, apoptosis and cell proliferation. Loss of
one or more InsP3R isoform has been implicated in disease processes such as cholestasis.
Here we examined whether gain of expression of InsP3R isoforms also may be associated
with development of disease. Expression of all three InsP3R isoforms was evaluated in
tissue from colorectal carcinomas surgically resected from 116 patients. Type I and II …
and regulates cellular functions such as secretion, apoptosis and cell proliferation. Loss of
one or more InsP3R isoform has been implicated in disease processes such as cholestasis.
Here we examined whether gain of expression of InsP3R isoforms also may be associated
with development of disease. Expression of all three InsP3R isoforms was evaluated in
tissue from colorectal carcinomas surgically resected from 116 patients. Type I and II …