[HTML][HTML] Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2-and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 …
HG Munshi, YI Wu, S Mukhopadhyay… - Journal of Biological …, 2004 - ASBMB
Acquisition of matrix metalloproteinase-2 (MMP-2) activity is temporally associated with
increased migration and invasiveness of cancer cells. ProMMP-2 activation requires
multimolecular complex assembly involving proMMP-2, membrane type 1-MMP (MT1-MMP,
MMP-14), and tissue inhibitor of metalloproteinases-2 (TIMP-2). Because transforming
growth factor-β1 (TGF-β1) promotes tumor invasion in advanced squamous cell carcinomas,
the role of TGF-β1 in the regulation of MMP activity in a cellular model of invasive oral …
increased migration and invasiveness of cancer cells. ProMMP-2 activation requires
multimolecular complex assembly involving proMMP-2, membrane type 1-MMP (MT1-MMP,
MMP-14), and tissue inhibitor of metalloproteinases-2 (TIMP-2). Because transforming
growth factor-β1 (TGF-β1) promotes tumor invasion in advanced squamous cell carcinomas,
the role of TGF-β1 in the regulation of MMP activity in a cellular model of invasive oral …