[HTML][HTML] Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals
C Handschin, S Chin, P Li, F Liu, E Maratos-Flier… - Journal of Biological …, 2007 - ASBMB
The transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator 1α
(PGC-1α) is a key integrator of neuromuscular activity in skeletal muscle. Ectopic expression
of PGC-1α in muscle results in increased mitochondrial number and function as well as an
increase in oxidative, fatigue-resistant muscle fibers. Whole body PGC-1α knock-out mice
have a very complex phenotype but do not have a marked skeletal muscle phenotype. We
thus analyzed skeletal muscle-specific PGC-1α knock-out mice to identify a specific role for …
(PGC-1α) is a key integrator of neuromuscular activity in skeletal muscle. Ectopic expression
of PGC-1α in muscle results in increased mitochondrial number and function as well as an
increase in oxidative, fatigue-resistant muscle fibers. Whole body PGC-1α knock-out mice
have a very complex phenotype but do not have a marked skeletal muscle phenotype. We
thus analyzed skeletal muscle-specific PGC-1α knock-out mice to identify a specific role for …