An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell
Islets, 2010•Taylor & Francis
Several recent reports, including one in this journal, have reignited the debate about
whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate
(NAADP) plays a central role in the regulation of calcium signalling in pancreatic β-cell. 1-5
These studies have highlighted a role for NAADP-induced Ca2+ mobilization not only in
mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin,
but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic …
whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate
(NAADP) plays a central role in the regulation of calcium signalling in pancreatic β-cell. 1-5
These studies have highlighted a role for NAADP-induced Ca2+ mobilization not only in
mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin,
but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic …
Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signalling in pancreatic β-cell.1-5 These studies have highlighted a role for NAADP-induced Ca2+ mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic β-cell.
Taylor & Francis Online