[HTML][HTML] Glucagon-like peptide 1 activates protein kinase C through Ca2+-dependent activation of phospholipase C in insulin-secreting cells

Y Suzuki, H Zhang, N Saito, I Kojima, T Urano… - Journal of biological …, 2006 - ASBMB
Although the stimulatory effect of glucagon-like peptide 1 (GLP-1), a cAMP-generating
agonist, on Ca 2+ signal and insulin secretion is well established, the underlying
mechanisms remain to be fully elucidated. We recently discovered that Ca 2+ influx alone
can activate conventional protein kinase C (PKC) as well as novel PKC in insulin-secreting
(INS-1) cells. Building on this earlier finding, here we examined whether GLP-1-evoked Ca
2+ signaling can activate PKCα and PKCϵ at a substimulatory concentration of glucose (3 …