Th17 cells in natural SIV hosts
M Paiardini - Current Opinion in HIV and AIDS, 2010 - journals.lww.com
Current Opinion in HIV and AIDS, 2010•journals.lww.com
A preferential depletion of mucosal Th17 cells is a feature that distinguishes pathogenic HIV
infection of humans from nonprogressive SIV infection of sooty mangabeys and AGMs. The
exact mechanism accounting for this different phenotype is still unclear. To understand how
natural hosts for SIV preserve Th17 cells and mucosal immunity might be central to the
development of therapeutic interventions aimed at improving mucosal immunity in HIV-
infected individuals.
infection of humans from nonprogressive SIV infection of sooty mangabeys and AGMs. The
exact mechanism accounting for this different phenotype is still unclear. To understand how
natural hosts for SIV preserve Th17 cells and mucosal immunity might be central to the
development of therapeutic interventions aimed at improving mucosal immunity in HIV-
infected individuals.
Summary
A preferential depletion of mucosal Th17 cells is a feature that distinguishes pathogenic HIV infection of humans from nonprogressive SIV infection of sooty mangabeys and AGMs. The exact mechanism accounting for this different phenotype is still unclear. To understand how natural hosts for SIV preserve Th17 cells and mucosal immunity might be central to the development of therapeutic interventions aimed at improving mucosal immunity in HIV-infected individuals.
Lippincott Williams & Wilkins