Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models
S Hara, D Kamei, Y Sasaki, A Tanemoto, Y Nakatani… - Biochimie, 2010 - Elsevier
Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived
prostaglandin H2 (PGH2) to PGE2, is known to comprise a group of at least three structurally
and biologically distinct enzymes. Two of them are membrane-bound and have been
designated as mPGES-1 and mPGES-2. mPGES-1 is a perinuclear protein that is markedly
induced by proinflammatory stimuli and downregulated by anti-inflammatory glucocorticoids
as in the case of COX-2. It is functionally coupled with COX-2 in marked preference to COX …
prostaglandin H2 (PGH2) to PGE2, is known to comprise a group of at least three structurally
and biologically distinct enzymes. Two of them are membrane-bound and have been
designated as mPGES-1 and mPGES-2. mPGES-1 is a perinuclear protein that is markedly
induced by proinflammatory stimuli and downregulated by anti-inflammatory glucocorticoids
as in the case of COX-2. It is functionally coupled with COX-2 in marked preference to COX …