[HTML][HTML] Wnt/β-catenin signaling and disease

H Clevers, R Nusse - Cell, 2012 - cell.com
Cell, 2012cell.com
The WNT signal transduction cascade controls myriad biological phenomena throughout
development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a
wide range of pathologies in humans. In this Review, we provide an update of the core
Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease,
and pose outstanding questions to be addressed in the future.
The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.
cell.com