[HTML][HTML] IRE1α controls cyclin A1 expression and promotes cell proliferation through XBP-1
JA Thorpe, SR Schwarze - Cell Stress and Chaperones, 2010 - Elsevier
IRE1 is a conserved dual endoribonuclease/protein kinase that is indispensable for directing
the endoplasmic reticulum (ER) stress response in yeast, flies, and worms. In mammalian
systems, however, the precise biological activities carried out by IRE1α are unclear. Here,
molecular and chemical genetic approaches were used to control IRE1 activity in a number
of prostate cancer cell lines and the resulting impact on gene transcription, cell survival, and
proliferation was examined. Modulating IRE1α activity had no transcriptional effect on the …
the endoplasmic reticulum (ER) stress response in yeast, flies, and worms. In mammalian
systems, however, the precise biological activities carried out by IRE1α are unclear. Here,
molecular and chemical genetic approaches were used to control IRE1 activity in a number
of prostate cancer cell lines and the resulting impact on gene transcription, cell survival, and
proliferation was examined. Modulating IRE1α activity had no transcriptional effect on the …