[HTML][HTML] A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6
T Okada, K Haze, S Nadanaka, H Yoshida… - Journal of Biological …, 2003 - ASBMB
Mammalian cells express several transcription factors embedded in the endoplasmic
reticulum (ER) as transmembrane proteins that are activated by proteolysis, and two types of
these proteins have been extensively investigated. One type comprises the sterol regulatory
element-binding proteins (SREBP-1 and SREBP-2). The other type comprises the activating
transcription factors 6 (ATF6α and ATF6β), which are activated in response to ER stress. It
was shown previously that both SREBP and ATF6 are cleaved sequentially first by the Site-1 …
reticulum (ER) as transmembrane proteins that are activated by proteolysis, and two types of
these proteins have been extensively investigated. One type comprises the sterol regulatory
element-binding proteins (SREBP-1 and SREBP-2). The other type comprises the activating
transcription factors 6 (ATF6α and ATF6β), which are activated in response to ER stress. It
was shown previously that both SREBP and ATF6 are cleaved sequentially first by the Site-1 …