[PDF][PDF] The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling
Cell stem cell, 2015•cell.com
Hepatocellular carcinoma (HCC) is the most prevalent subtype of liver cancer, and it is
characterized by a high rate of recurrence and heterogeneity. Liver cancer stem cells
(CSCs) may well contribute to both of these pathological properties, but the mechanisms
underlying their self-renewal and maintenance are poorly understood. Here, using
transcriptome microarray analysis, we identified a long noncoding RNA (lncRNA) termed
lncTCF7 that is highly expressed in HCC tumors and liver CSCs. LncTCF7 is required for …
characterized by a high rate of recurrence and heterogeneity. Liver cancer stem cells
(CSCs) may well contribute to both of these pathological properties, but the mechanisms
underlying their self-renewal and maintenance are poorly understood. Here, using
transcriptome microarray analysis, we identified a long noncoding RNA (lncRNA) termed
lncTCF7 that is highly expressed in HCC tumors and liver CSCs. LncTCF7 is required for …
Summary
Hepatocellular carcinoma (HCC) is the most prevalent subtype of liver cancer, and it is characterized by a high rate of recurrence and heterogeneity. Liver cancer stem cells (CSCs) may well contribute to both of these pathological properties, but the mechanisms underlying their self-renewal and maintenance are poorly understood. Here, using transcriptome microarray analysis, we identified a long noncoding RNA (lncRNA) termed lncTCF7 that is highly expressed in HCC tumors and liver CSCs. LncTCF7 is required for liver CSC self-renewal and tumor propagation. Mechanistically, lncTCF7 recruits the SWI/SNF complex to the promoter of TCF7 to regulate its expression, leading to activation of Wnt signaling. Our data suggest that lncTCF7-mediated Wnt signaling primes liver CSC self-renewal and tumor propagation. In sum, therefore, we have identified an lncRNA-based Wnt signaling regulatory circuit that promotes tumorigenic activity in liver cancer stem cells, highlighting the role that lncRNAs can play in tumor growth and propagation.
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