Expression and localization of platelet-activating factor receptor in human nasal mucosa
H Shirasaki, N Seki, M Kikuchi, E Kanaizumi… - Annals of Allergy …, 2005 - Elsevier
BACKGROUND: Platelet-activating factor (PAF) has been thought to be a potent mediator of
allergic rhinitis because PAF was recovered from the nasal lavage fluid of patients with
allergic rhinitis after allergen provocation. Furthermore, PAF receptor antagonist attenuates
the antigen-induced increase in nasal airway resistance and nasal vascular permeability in
sensitized guinea pigs. OBJECTIVE: To clarify the expression of PAF receptor in human
nasal mucosa by investigating PAF receptor messenger RNA (mRNA) expression and its …
allergic rhinitis because PAF was recovered from the nasal lavage fluid of patients with
allergic rhinitis after allergen provocation. Furthermore, PAF receptor antagonist attenuates
the antigen-induced increase in nasal airway resistance and nasal vascular permeability in
sensitized guinea pigs. OBJECTIVE: To clarify the expression of PAF receptor in human
nasal mucosa by investigating PAF receptor messenger RNA (mRNA) expression and its …