STAT1 as a novel therapeutical target in pro-atherogenic signal integration of IFNγ, TLR4 and IL-6 in vascular disease
K Sikorski, A Czerwoniec, JM Bujnicki, J Wesoly… - Cytokine & growth factor …, 2011 - Elsevier
Inflammation participates importantly in host defenses against infectious agents and injury,
but it also contributes to the pathophysiology of atherosclerosis. Recruitment of blood
leukocytes to the injured vascular endothelium characterizes the initiation and progression
of atherosclerosis and involves many inflammatory mediators, modulated by cells of both
innate and adaptive immunity. The pro-inflammatory cytokine, interferon (IFN)-γ derived from
T cells, is vital for both innate and adaptive immunity and is also expressed at high levels in …
but it also contributes to the pathophysiology of atherosclerosis. Recruitment of blood
leukocytes to the injured vascular endothelium characterizes the initiation and progression
of atherosclerosis and involves many inflammatory mediators, modulated by cells of both
innate and adaptive immunity. The pro-inflammatory cytokine, interferon (IFN)-γ derived from
T cells, is vital for both innate and adaptive immunity and is also expressed at high levels in …