A fascinating question of modern biology is how a limited number of signaling pathways
generate biological diversity and crosstalk phenomena in vivo. Well-defined
posttranslational modification patterns dictate the functions and interactions of proteins. The
signal transducers and activators of transcription (STATs) are physiologically important
cytokine-induced transcription factors. They are targeted by a multitude of posttranslational
modifications that control and modulate signaling responses and gene expression. Beyond …