Mechanisms of peptide vaccination in mouse models: tolerance, immunity, and hyperreactivity
T van Hall, SH van der Burg - Advances in immunology, 2012 - Elsevier
The development of synthetic peptide vaccines capable of inducing strong and protective T-
cell immunity has taken more than 20 years. Peptide vaccines come in many flavors and
although their design is simple, their use is more complicated as the success of a particular
peptide vaccine is influenced by many parameters. In fact, peptide vaccination may lead to
tolerance, immunity or even hyper-reactivity causing death of the animals. Here we
systematically dissect the parameters that influence the final outcome of peptide vaccines as …
cell immunity has taken more than 20 years. Peptide vaccines come in many flavors and
although their design is simple, their use is more complicated as the success of a particular
peptide vaccine is influenced by many parameters. In fact, peptide vaccination may lead to
tolerance, immunity or even hyper-reactivity causing death of the animals. Here we
systematically dissect the parameters that influence the final outcome of peptide vaccines as …