Immune adjuvants as critical guides directing immunity triggered by therapeutic cancer vaccines

V Schijns, E Tartour, J Michalek, A Stathopoulos… - Cytotherapy, 2014 - Elsevier
Tumor growth is controlled by natural antitumor immune responses alone or by augmented
immune reactivity resulting from different forms of immunotherapy, which has demonstrated
clinical benefit in numerous studies, although the overall percentage of patients with durable
clinical responses remains limited. This is attributed to the heterogeneity of the disease, the
inclusion of late-stage patients with no other treatment options and advanced tumor-
associated immunosuppression, which may be consolidated by certain types of …