TGF-β: guardian of T cell function

SA Oh, MO Li - The Journal of Immunology, 2013 - journals.aai.org
SA Oh, MO Li
The Journal of Immunology, 2013journals.aai.org
A fundamental aspect of the adaptive immune system is the generation and maintenance of
a diverse and self-tolerant T cell repertoire. Through its regulation of T cell development,
homeostasis, tolerance, and differentiation, the highly evolutionarily conserved cytokine TGF-
β critically supports a functional T cell pool. The pleiotropic nature of this regulation is likely
due to the elaborate control of TGF-β production and activation in the immune system, and
the intricacy of TGF-β signaling pathways. In this review we discuss the current …
Abstract
A fundamental aspect of the adaptive immune system is the generation and maintenance of a diverse and self-tolerant T cell repertoire. Through its regulation of T cell development, homeostasis, tolerance, and differentiation, the highly evolutionarily conserved cytokine TGF-β critically supports a functional T cell pool. The pleiotropic nature of this regulation is likely due to the elaborate control of TGF-β production and activation in the immune system, and the intricacy of TGF-β signaling pathways. In this review we discuss the current understanding of TGF-β regulation of T cells.
journals.aai.org